Abstract #4055

Gray-White Matter Boundary Z-Score and Its Volume as Imaging Biomarkers of Alzheimer’s Disease

Geon-Ho Jahng¹, Yunan Tian², Jang-Hoon Oh³, Hak Young Rhee⁴, Soonchan Park¹, Chang-Woo Ryu¹, and Wook Jin¹

¹Radiology, Kyung Hee University Hospital at Gangdong, Seoul, Korea, Republic of, ²Kyung Hee University, Seoul, Korea, Republic of, ³Radiology, Kyung Hee University Hospital, Seoul, Korea, Republic of, ⁴Neurology, Kyung Hee University Hospital at Gangdong, Seoul, Korea, Republic of

Synopsis

Keywords: Alzheimer's Disease, Alzheimer's Disease, gray-white matter boundary

Motivation: Alzheimer's disease (AD) presents typically gray matter atrophy and white matter abnormalities in neuroimaging.

Goal(s): Exploring gray-white matter boundary Z-score (gwBZ) and its tissue volume (gwBTV) between patients with Alzheimer’s disease (AD), amnestic mild cognitive impairment (MCI), and cognitively normal (CN) elderly participants.

Approach: Three-dimensional T1-weight images of a total of 227 participants were acquired to calculate gwBZ and gwBTV, prospectively.

Results: Both gwBZ and gwBTV were reduced in AD, were positively correlated with cognitive function, and could accurately discriminate AD from CN .

Impact: gwBZ and gwBTV could be a useful tool for monitoring AD progression and diagnosis.

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