Keywords: Other Neurodegeneration, Brain, glymphatic system, chronic insomnia
Motivation: Long-term chronic insomnia is considered to be a high risk factor for dementia,but the relationship between insomnia and glymphatic activity is unclear.
Goal(s): Aim to explore the relationship between the changes of DTI-ALPS index and mental and psychological performance in chronic insomnia patients.
Approach: 20 patients diagnosed with chronic insomnia (CR) and 20 control subjects (HC) , MRI scanning, and DTI-ALPS analysis.
Results: The glymphatic function activity of individuals with chronic insomnia is lower compared to the normal control group, and age independently influences this. There were significant correlation between the DTI-ALPS index, the scores of PSQI and MMSE.
Impact: Chronic insomnia can cause a decrease in brain glymphatic function, and age is an independent factor that affects glymphatic function. Additionally, sleep quality and neuropsychological performance are also related to changes in glymphatic function.
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