Abstract #4063

Revealing abnormal brain motion in patients with neurodegenerative diseases using 3D quantitative-amplified MRI - A preliminary study

Itamar Terem¹, Kyan Younes², Hillary Vossler², Elizabeth Mormino², Daniel Cornfeld³, Kristen Yeom⁴, Raag Airan⁵, Samantha Holdsworth^3,6, and Kawin Setsompop⁵

¹Electrical Engineering, Stanford, Stanford, CA, United States, ²Neurology & Neurological Sciences, Stanford, Stanford, CA, United States, ³Mātai Medical Research Institute, Tairāwhiti-Gisborne, New Zealand, ⁴Phoenix Children's Hospital, Phoenix, AZ, United States, ⁵Radiology, Stanford, Stanford, CA, United States, ⁶Faculty of Medical & Health Sciences & Centre for Brain Research, University of Auckland, Auckland, New Zealand

Synopsis

Keywords: Dementia, Neurodegeneration, 3D amplified MRI (aMRI), Neurofluids

Motivation: 3D q-aMRI is a method for visualizing and quantifying the pulsatile brain sub-voxel displacement field. Here, we explore the potential of pulsatile brain motion as a biomarker for classification of common neurodegenerative diseases

Goal(s): To explore the ability of 3D q-aMRI to detect abnormal brain motion in patients with common neurodegenerative diseases

Approach: The 3D q-aMRI outputs in 15 patients with different neurodegenerative diseases such mild cognitive impairment (MCI) due to Alzheimer's disease (AD), lewy body dementia (LBD), dementia due to AD were evaluated, and compared with healthy controls.

Results: 3D q-aMRI revealed abnormal motion in patients with neurodegenerative diseases.

Impact: 3D quantitative-amplified MRI is a pulsatile brain motion visualization and quantification method. Exploring pulsatile brain motion as a potential biomarker for neurodegenerative diseases classification is of great importance. 3D q-aMRI revealed abnormal pulsatile brain motion in patients with neurodegenerative diseases.

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