Keywords: Dementia, Blood vessels, Atherosclerosis, Brain, Pathology, Ex-vivo applications, Hippocampus, Neurodegeneration, Vascular
Motivation: Intracranial atherosclerosis is a common and deleterious age-related neuropathology, however, its association with brain morphometry has not been investigated.
Goal(s): To investigate brain morphometric anomalies associated with intracranial atherosclerosis in a large number of community-based older adults.
Approach: Ex-vivo brain MRI and detailed neuropathologic examination were combined on 891 community-based older adults. Deformation-based morphometry (DBM) was used to investigate the association of intracranial atherosclerosis with brain morphometric characteristics voxel-wise.
Results: Intracranial atherosclerosis was associated with lower volume in the posterior body and tail of the hippocampus in linear regression models controlling for all other neuropathologies.
Impact: Intracranial atherosclerosis is the third age-related neuropathology after Alzheimer’s and limbic-predominant age-related TDP-43 encephalopathy (LATE) that is shown to be independently associated with lower volume of the hippocampus.
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