Keywords: Dementia, Dementia
Motivation: Brain damage in end-stage renal disease patients with mild cognitive impairment (ESRD-MCI) has not yet been elucidated.
Goal(s): Our goal was to determine the characteristics of alterations in gray matter (GM) structure and the neurobiological mechanisms in ESRD-MCI patients.
Approach: We utilized voxel-based morphology to analyze GM volume alterations in ESRD-MCI patients.
Results: Results demonstrated that MCI in ESRD patients was predominantly impaired in the left middle temporal gyrus, completely mediating the effect of serum phosphorus on MCI.
Impact: Our demonstration of a detectable volume decline in the left middle temporal gyrus utilizing structural MRI provides a quantitative metric to be utilized within clinical therapy trials for intervention of MCI in ESRD patients.
How to access this content:
For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.
After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.
After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.
Keywords