Keywords: Neurofluids, Neurofluids
Motivation: It is desirable to accurately evaluate water movement within the brain so that it can be compared with neurofluid flow observed with other tracers.
Goal(s): The aim of this study was to evaluate the motion of neurofluids in a mouse model of chronic unilateral hypoperfusion using H217O and Gd-DTPA as MRI tracers.
Approach: Dynamic T2WI and T1WI were performed during and after intrathecal infusion of H217O and Gd-DTPA, respectively.
Results: There was a clear difference in the distributions of H217O and Gd-DTPA after intrathecal injection. This suggests that different mechanisms are involved in the transport of water and other molecules in the brain.
Impact: The difference in distribution of the tracers in the UCCAO model suggests that this method may be useful for investigating the pathological mechanism of various brain diseases.
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