Meeting Banner
Abstract #4113

Progressive brain volume alterations in the zQ175DN mouse model of Huntington’s Disease using in vivo MRI

Nicholas Vidas-Guscic1,2, Tamara Vasilkovska1,2, Stefanie Pluym1, Joëlle van Rijswijk1,2, Johan Van Audekerke1,2, Haiying Tang3, Roger Cachope3, Dorian Pustina3, Annemie Van der Linden1, Daniele Bertoglio1,2, and Marleen Verhoye1,2
1Bio-Imaging Lab, University of Antwerp, Wilrijk, Belgium, 2µNeuro Center for Excellence, University of Antwerp, Wilrijk, Belgium, 3CHDI Foundation Inc, Princeton, NJ, United States

Synopsis

Keywords: Small Animals, Genetic Diseases, Volumetric

Motivation: Robust translational imaging biomarkers are needed to facilitate the development of disease-modifying treatments for Huntington’s disease (HD), a rare inherited neurodegenerative disease.

Goal(s): To determine the use of structural atrophy determined with MRI as a robust translational biomarker for testing therapeutics in mouse models prior to people with HD.

Approach: In this work, we used semi-automatic delineations and tensor-based morphometry (TBM) of 3D high-resolution anatomical MR images to assess structural anomalies in the knock-in zQ175DN model of HD at different ages.

Results: We detected progressive volumetric decrease in the zQ175DN mouse model, offering a powerful translational biomarker for the assessment of disease-modifying therapies.

Impact: We report the first brain-wide structural study of zQ175DN mice using in vivo MRI. Our work supports structural atrophy as a robust translational biomarker for testing therapeutics in mouse models prior to people with HD.

How to access this content:

For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.

After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.

After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.

Click here for more information on becoming a member.

Keywords