Abstract #4120

Application of zero-echo time pulse sequence for functional MRI.

Ayako Imamura^1,2,3, Rikita Araki⁴, Yukari Takahashi³, Koichi Miyatake², Fusao Kato³, Sakiko Honjoh², and Tomokazu Tsurugizawa^5,6

¹Ph. D. Program in Humanics, University of Tsukuba, Tsukuba, Japan, ²International Institute for Integrative Sleep Medicine (WPI-IIIS), Tsukuba, Japan, ³Department of Neuroscience, The Jikei University School of Medicine, Tokyo, Japan, ⁴Bruker Japan K.K., Yokohama, Japan, ⁵Human Informatics and Interaction Research Institute, National Institute of Advanced Industrial Science and Technology (AIST), Tsukuba, Japan, ⁶Faculty of Engineering, University of Tsukuba, Tsukuba, Japan

Synopsis

Keywords: Small Animals, Preclinical

Motivation: Zero-echo time (ZTE) sequence reduces susceptibility artifacts compared to echo planar imaging (EPI). However, the feasibility of ZTE for functional MRI (fMRI) has not been fully investigated.

Goal(s): Our goal was to assess the feasibility of ZTE for fMRI.

Approach: Time-course of ZTE, gradient echo (GE)-EPI, and spin echo (SE)-EPI signal changes by somatosensory stimulation was investigated. The functional connectivity in resting state ZTE, GE-EPI, SE-EPI was also compared.

Results: The results indicate that ZTE is useful for fMRI.

Impact: ZTE sequences realize the fMRI that is robust to susceptibility artifacts.

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