Keywords: Preclinical Image Analysis, Spectroscopy, animals, aging, spectroscopy, treatment, Rho GTPases
Motivation: RhoGTPases are involved in the pathogenesis of neurodegenerative and neurodevelopmental diseases, playing a key role in synaptic plasticity.
Goal(s): The aim is to evaluate the involvement of RhoGTPases on ageing processes, assessing effects of RhoGTPases modulation on behavior and brain metabolism (by MRS) on a healthy aging mouse model.
Approach: We pharmacologically modulated RhoGTPases pathways by administering fasudil or CNF1 in mice. Animals are subjected to behavioral tests and to MRI/MRS experiments in frontal cortex, hippocampus and cerebellum.
Results: Young mice showed apparent greater anxiolytic effect respect to old mice. We observed also age- differences in the metabolism in response to both treatments.
Impact: Dysregulation of the RhoGTPase pathway leads to: oxidative stress, inflammation, alterations in energy metabolism and reduced synaptic transmission. RhoGTPase pathway is involved in the pathogenesis of neurodegenerative diseases; RhoGTPases are here proposed as an innovative pharmacological target for their treatment.
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