Abstract #4130

Mammalian Species: Development of Basic Tools for Standardized Brain Image Analysis

Miyu Okazaki¹, Junichi Hata², Kanako Muta², Karen Kurokawa², Hinako Oshiro², Kie Yamamoto³, Dai Nagakubo³, and Ryohei Nishimura⁴

¹Faculty of Health Sciences, Tokyo Metropolitan University, Tokyo, Japan, ²Graduate school of Human Health Sciences, Tokyo Metropolitan Uiniversity, Tokyo, Japan, ³Veterinary Medical Center, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Tokyo, Japan, ⁴Laboratory of Veterinary Surgery, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Tokyo, Japan

Synopsis

Keywords: Large Animals, Nonhuman Primates, Animals

Motivation: Establishing standard brain images for various mammalian species may be useful in brain imaging analysis.

Goal(s): The current research aimed to establish a foundation for brain image analysis tools in a variety of mammalian species, including cats and marmosets, for which standard brain data are scarce.

Approach: For each species, we attempted to create an image of average brain using a nonrigid transformation algorithm. We also evaluated the quality of the average brain images by changing the number of subjects.

Results: We were able to create an image the average human, cat, marmoset, and mouse brain based on T1- and T2-weighted images.

Impact: This study provides an important foundation for the creation of standard brain images of various animal species and for the evaluation of individual differences.

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