Keywords: Epilepsy, Hyperpolarized MR (Non-Gas)
Motivation: Thirty percent of epilepsy patients have seizures despite best medical therapies. Therefore, a non-invasive method to localize seizure onset zone (SOZ) and epilepsy network (EN) in epilepsy surgery to improve surgical outcomes is essential.
Goal(s): The goal of this study was to apply dynamic magnetic resonance spectroscopic imaging (MRSI) of hyperpolarized [1‑13C]pyruvate (Pyr) to measure lactate (Lac) release in a Pentylenetetrazol (PTZ) mouse model of epilepsy.
Approach: We hypothesize that hpMRSI of [1-13C]Pyr accurately measures elevated Pyr-to-Lac conversion in a PTZ mouse model of epilepsy.
Results: Significant increase in Pyr-to-Lac conversion has been measured in PTZ kindled mice compared to control mice.
Impact: Epilepsy surgery outcomes depend on correctly identifying SOZ and EN. We utilized hpMRSI of [1-13C]Pyr to accurately identify elevated Lac release in PTZ mouse model of epilepsy. These results support its potential application to identify epileptic focus in epilepsy patients.
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