Abstract #4140

Enhancing liver reserve function prediction in liver cancer through Gd-EOB-DTPA and DWI: Insights on CD34 and glypican-3 expression levels

Song Chen^1,2, Lanbin Huang³, Jiayuan Chen³, Yuexing Huang³, Quanneng Su³, Mengzhu Wang⁴, Chen Zhao⁴, Qizeng Ruan³, Qingchun Li³, Mingxia Tan³, and Zehe Huang³

¹Department of Radiology, The First People's Hospita of Qinzhou, Qinzhou, China, ²The First People's Hospita of Qinzhou, Qinzhou, China, ³Department of Radiology, The First People's Hospital of QinZhou, Qinzhou, China, ⁴Siemens Healthineers Ltd, Beijing, China

Synopsis

Keywords: Liver, Cancer, Gd-EOB-DTPA；ADC；CD34；Glypican-3

Motivation: The quantitative magnetic resonance imaging of Gd-EOB-DTPA has been employed to predict liver reserve function, tolerance, and postoperative recovery in patients with primary liver cancer.

Goal(s): To investigate the relationship between quantitative parameters, liver reserve function of primary liver cancer and the expression levels of CD34 and Glypican-3.

Approach: Evaluate the correlation between RE_HBP, ADC, liver function classification, and immune markers CD34 and Glypican-3

Results: In comparison to patients with benign liver nodules, patients with primary liver cancer exhibited significantly lower RE_HBP and ADC values.

Impact: The combination DCE-MRI with Gd-EOB-DTPA and DWI has a predictive value for liver reserve function and prognostic molecular marker expression in patients with primary liver cancer. It can also serve as a useful reference index for clinical preoperative planning.

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