Abstract #4142

Simplified LI-RADS Table for Hepatocellular Carcinoma Diagnosis on Extracellular-Contrast Enhanced MRI: AFP as an Additional Major Feature

Jinhui Zhou¹, Yao Zhang², Jing Zhang³, Jingbiao Chen¹, Hang Jiang¹, Yu Han¹, Linqi Zhang¹, Xi Zhong⁴, Tianhui Zhang⁵, Lichun Chen⁶, Yufeng Wang⁶, Yikai Xu³, Yang Yang⁷, and Jin Wang¹

¹Department of Radiology, The Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, China, ²Department of Radiology, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, China, ³Department of Medical Imaging Center, Nanfang Hospital, Southern Medical University, Guangzhou, China, ⁴Department of Radiology, Affiliated Cancer Hospital & Institute of Guangzhou Medical University, Guangzhou, China, ⁵Department of Radiology, Meizhou People's Hospital, Meizhou, China, ⁶Department of Radiology, The Third Affiliated Hospital of Sun Yat-sen University Yuedong Hospital, Meizhou, China, ⁷Department of Hepatic Surgery and Liver transplantation Center, The Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, China

Synopsis

Keywords: Liver, Tumor, LI-RADS, AFP

Motivation: The MRI LI-RADS v2018 table is complex and has insufficient sensitivity.

Goal(s): To evaluate the diagnostic performance of the simplified LI-RADS table for HCC on ECA-MRI, and to determine the value of AFP level as an additional major feature.

Approach: We developed and compared the per-lesion sensitivity for HCC defined by LI-RADS v2018, simplified LI-RADS table, and both of them combined with AFP ≥ 200 ng/mL.

Results: Compared with LR-5 v2018, the simplified LI-RADS table provided higher sensitivity and comparable specificity for HCC. AFP ≥ 200 ng/mL may be a suitable additional major feature for further improving LR-5 v2018 and sLR-5 classification.

Impact: Our simplified LI-RADS table may be more convenient and clinically helpful, and the AFP ≥ 200 ng/mL may be a suitable additional major feature for accurate LR-5 and sLR-5 classification.

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