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Abstract #4169

UPsampling by Subspace Informed ZEro-padded Reconstruction (UPSIZER) in Diffusion Tensor Imaging

Neale Wiley1, Sharada Balaji1, Adam Dvorak1, Irene Vavasour1, and Shannon Kolind2
1Physics and Astronomy, University of British Columbia, Vancouver, BC, Canada, 2Medicine, University of British Columbia, Vancouver, BC, Canada

Synopsis

Keywords: Sparse & Low-Rank Models, Diffusion Tensor Imaging

Motivation: Diffusion tensor imaging (DTI) is inherently resolution limited by MRI gradient performance and human tolerance of gradient slew rates but could benefit greatly from finer detail for tissue mapping.

Goal(s): To increase the resolution of DTI images by using the joint information between different encoding directions to improve efficiency of upsampling.

Approach: Using a compressed sensing subspace-based reconstruction algorithm on zero-padded k-space to estimate a higher resolution image with finer detail than current interpolation strategies.

Results: Smoother diffusion encoded images and reduced spatial blurring in calculated metrics compared to standard cubic interpolation was achieved.

Impact: A new method for upsampling diffusion images using subspace-based compressed sensing reconstruction is introduced that includes fine detail and reduces noise. Potential for improving on standard cubic interpolation is demonstrated, which will benefit DTI analysis including tractography.

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Keywords