Keywords: Sparse & Low-Rank Models, Hyperpolarized MR (Non-Gas), Kidney, MR Fingerprinting, Metabolism
Motivation: T1 of hyperpolarized Carbon-13 (HP-13C) molecules results in limited data acquisition period. In conventional imaging approaches, this results in sacrifices in imaging resolution, which leads to limited sensitive and interpretability of results.
Goal(s): Combine efficient MR fingerprinting based acquisition with spatiotemporal low-rank constraint for accelerated high resolution metabolic imaging.
Approach: bSSFP-type MRF acquisition was reconstructed iteratively with low-rank temporal constraint derived from HP-13C signal model. Method was assessed in digital phantom, retrospective, and prospective preclinical rat kidney.
Results: Strong undersampling capacity was observed in simulation and retrospective studies. Preclinical experiment with 20-fold smaller voxel volume showed reasonable results.
Impact: Improved resolution is a critical prerequisite for clinical utility of HP-13C measurements. The methods shown here demonstrate potential for robust metabolic measurements at order of magnitude higher resolution, and is adaptable for wide range of organ systems and metabolic processes.
How to access this content:
For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.
After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.
After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.
Keywords