Keywords: Parkinson's Disease, Parkinson's Disease
Motivation: Different vulnerabilities of hippocampal subfields in PD and MCI have been reported.
Goal(s): To explore the discrepancy of hippocampal subfield atrophy and its FC pattern in HC, PDNCI, PDMCI, and MCI patients.
Approach: Volume of hippocampal subfields, and FC between impaired subfields and cortical regions were calculated to assess group differences.
Results: PD groups had reduced volumes in CA2/3, CA4, and GC-DG subfields and increased FC in the visual network.MCI group exhibited decreased right CA4 volume and increased FC in the widespread visual network.PDMCI displayed enhanced FC in the DMN compared to PDNCI and decreased FC in the visual network relative to MCI.
Impact: As cognitive decline advances in PD, FC alterations are prominent between the GC-DG+CA4 subfield and the DMN. Smaller hippocampal subfield and its widespread FC abnormalities in MCI relative to PDMCI may underscore the different progression mechanisms of the two diseases.
How to access this content:
For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.
After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.
After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.
Keywords