Keywords: Alzheimer's Disease, Brain, Morphometry; Spectroscopy; cell-free DNA; Biomarkers;
Motivation: There is a lack of biomarkers in elderly people with ongoing subjective or clinical cognitive decline that indicate evolution to Alzheimer’s disease, necessary for the timely identification of candidate for pharmacological treatment or cognitive rehabilitation.
Goal(s): Our goal was to determine whether combining MR, neuropsychological and biological data could provide robust biomarkers for this purpose.
Approach: We evaluated patients with subjective cognitive decline, mild cognitive impairment, Alzheimer’s disease and healthy individuals, using a multimodal approach.
Results: We identified candidate biomarkers of condition worsening at early stages of the disease among alterations possibly explained by ongoing neurodegeneration.
Impact: Our results support the combined investigation of imaging, biological and neuropsychological data to detect patients in the early stages of the Alzheimer’s disease spectrum, who may undergo active neurodegeneration and worsening of the condition.
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