Keywords: Alzheimer's Disease, Metabolism, 1H-[13C]-NMR, cognition, amyloid-beta plaque, glutamate, GABA, glucose
Motivation: Alzheimer’s Disease (AD) is the major form of dementia but there is no biomarker(s) and treatment available.
Goal(s): This study aimed to investigate how decline in cognitive function is manifested in neurometabolic activity with the progression of AD.
Approach: 5xFAD mice (6- and 12-month) were subjected to memory assessment using the Morris Water Maze test followed by neurometabolic analysis using 1H-[13C]-NMR spectroscopy in conjunction with an infusion of [1,6-13C2]glucose or [2-13C]acetate.
Results: The findings of the study suggest enhanced neuroinflammation, and reduced glutamatergic and GABAergic neurotransmission in 5xFAD mice.
Impact: 13C NMR based assessment of neuronal and astroglial metabolic activity may help get an insight into AD pathology, thus providing biomarker(s) for the diagnosis of AD.
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