Keywords: Other Neurodegeneration, Neurodegeneration, Progressive supranuclear palsy
Motivation: The subthalamic nucleus (STN) volumes have not been fully assessed in progressive supranuclear palsy (PSP) and Parkinson’s disease (PD).
Goal(s): Our goal was to explore diagnostic accuracy of STN volumes in PSP and PD.
Approach: We measured the volumes of the STN, brainstem, and superior cerebellar peduncle in PSP and PD patients.
Results: The STN volumes in patients with PSP were significantly reduced compared to those with PD patients. Furthermore, there was a significant negative correlation between the STN volume and disease duration in PSP patients.
Impact: The use of high-spatial-resolution QSM to measure the STN volume has potential as a diagnostic marker for PSP, as well as for monitoring the progression of the disease.
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