Abstract #4203

Brain iron deposition and cognitive decline in cerebral small vessel disease patients: A quantitative susceptibility mapping study

Yian Gao¹, QIhao Zhang², Hangwei Zhuang², Chaofan Sui¹, Nan Zhang¹, Mengmeng Feng³, Haotian Xin³, Changhu Liang¹, Lingfei Guo¹, Lingfei Guo¹, Lingfei Guo¹, and Yi Wang⁴

¹Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, China, ²Weill Medical College of Cornell University, New York, NY, United States, ³Xuanwu Hospital, Capital Medical University, Beijing, China, ⁴Weill Cornell Medical College, New York, NY, United States

Synopsis

Keywords: Other Neurodegeneration, Neurodegeneration

Motivation: Brain iron deposition and analysis of risk factors in cerebral small vessel disease patients with different total cerebral small vessel disease (CSVD) scores

Goal(s): Our study compares brain iron deposition in gray matter (GM) nuclei between CSVD patients and healthy controls (HCs), exploring factors that affect iron deposition and cognitive function.

Approach: Brain iron load was assessed using quantitative susceptibility mapping.

Results: Age, diabetes, and smoking may increase iron deposition in the basal ganglia, associated with cognitive decline. The mean susceptibility values of the neostriatum played a mediating role in the association between hypertension and cognitive scores.

Impact: Age, diabetes and smoking history could exacerbate local brain iron deposition. The iron deposition in the neostriatum plays a mediating role in the association between hypertension and executive function.

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