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Abstract #4205

1H-MRSI of the Globus Pallidus and White Matter in Patients With Amyotrophic Lateral Sclerosis

Meryem Torlak1,2, Gökçe Hale Hatay2, Barış İşak3, Dilaver Kaya4, Alp Dinçer5, Alpay Özcan6, and Esin Ozturk-Isik2
1Biomedical Engineering, Istanbul Technical University, Istanbul, Turkey, 2Institute of Biomedical Engineering, Bogazici University, Istanbul, Turkey, 3Department of Neurology, Marmara University, Istanbul, Turkey, 4Department of Neurology, Acıbadem University, Istanbul, Turkey, 5Department of Radiology, Acıbadem University, Istanbul, Turkey, 6Department of Electrical and Electronics Engineering, Boğaziçi University, Istanbul, Turkey

Synopsis

Keywords: Other Neurodegeneration, Neurodegeneration, Amyotrophic Lateral Sclerosis

Motivation: There is a need to understand the metabolic effects of Amyotrophic lateral sclerosis(ALS) in more brain regions, including globus pallidus that has a role in controlling conscious and proprioceptive movement.

Goal(s): To evaluate metabolic differences of ALS patients and healthy controls(HC) at the white matter(WM) and globus pallidus(GP).

Approach: LCModel was used to quantify multivoxel MR spectral data of ALS patients and HC. Metabolite peak ratios of these groups were compared at WM and GP regions.

Results: Lower Glu/tCr ratio at left WM than right side, lower GSH/tCr ratio at GP, and lower tNAA/tCr ratio at WM of ALS patients were observed.

Impact: Glu/tCr, GSH/tCr and tNAA/tCr ratio differences were identified at globus pallidus and white matter as possible biomarkers of ALS disease, which might affect treatment planning in ALS patients in the future.

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Abstract

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