Abstract #4215

MRA Derived Cerebral Arterial Flow Features Associated with White Matter Hyperintensity

Boyu Zhang^1,2,3, Yan Han⁴, Yajing Huo⁴, Zidong Yang^5,6, Hongwei Li^1,2, Huihui Lv⁴, and He Wang^1,2,7

¹Institute of Science and Technology for Brain-Inspired Intelligence, Fudan University, Shanghai, China, ²Key Laboratory of Computational Neuroscience and Brain-Inspired Intelligence (Fudan University), Ministry of Education, Shanghai, China, ³Department of Materials Science, Fudan University, Shanghai, China, ⁴Department of Neurology, Yueyang Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai, China, ⁵USC Viterbi School of Engineering, University of Southern California, Shanghai, China, ⁶Laboratory of FMRI Technology, USC Mark & Mary Stevens Neuroimaging and Informatics Institute, Keck School of Medicine, University of Southern California, Shanghai, China, ⁷Department of Neurology, Zhongshan Hospital, Fudan University, Shanghai, China

Synopsis

Keywords: Blood Vessels, Blood vessels, White matter hyperintensity, hemodynamic

Motivation: The morphology of cerebral arteries contributes to the development of white matter hyperintensity (WMH), yet the influence of arterial blood flow on WMH remains unclear.

Goal(s): Identify associations of cerebral arterial flow features with WMH.

Approach: 2631 individuals were involved. Arterial flow features were obtained using the individual-specific simplified hemodynamic model. WMHs were quantified from T2-FLAIR images.

Results: Both increased mean flow rate and pressure were associated with increased WMH volume. Adjacent Lesion Terminal Arterial Branches exhibited greater length, tortuosity, lower mean flow rates and pressure drops.

Impact: The hemodynamic features surrounding WMH exhibited significant difference compared to distant arteries. Such morphology and corresponding hemodynamic changes might contribute to the development of WMH.

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