Abstract #4225

Investigation of hippocampal subfield volumes in long COVID and ME/CFS using 7T MRI

Kiran Thapaliya¹, Sonya Marshall-Gradisnik¹, Natalie Eaton-Fitch¹, Markus Barth², Maira Inderyas¹, and Leighton Barnden¹

¹National Centre for Neuroimmunology and Emerging Diseases, Griffith University, Gold Coast, Australia, ²The University of Queensland, Brisbane, Australia

Synopsis

Keywords: Infectious Disease, COVID-19, ME/CFS, hippocampus, infectious disease

Motivation: To study hippocampal atrophy in long COVID and Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS patients).

Goal(s): Our goal was to investigate hippocampal atrophy in long COVID and ME/CFS patients.

Approach: We used T1-weighted MP2RAGE data from 7T MRI and used FreeSurfer to estimate hippocampal subfield volumes in long COVID and ME/CFS patients.

Results: We found that hippocampal subfield volumes were larger in long COVID and ME/CFS patients compared to HC.

Impact: Our study showed atypical hippocampal atrophy in long COVID and ME/CFS patients indicating that existing brain research findings in ME/CFS patients may help better understand the neurological dysfunction in long COVID patients.

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