Abstract #4236

Test-retest reliability of cerebral blood flow for assessing brain activity in a single day

Bowen Guo^1,2, Tianxin Mao^1,2, and Hengyi Rao^1,2

¹Center for Magnetic Resonance Imaging Research & Key Laboratory of Brain-Machine Intelligence for Information Behavior (Ministry of Education and Shanghai), Shanghai, China, ²School of Business and Management, Shanghai International Studies University, Shanghai, China

Synopsis

Keywords: Task/Intervention Based fMRI, fMRI

Motivation: Test-retest reliability of human activity in a single day has not yet been elucidated.

Goal(s): To determine the reliability of ASL perfusion MRI within a single day and determine the diurnal impact on the test-retest reliability of fMRI.

Approach: Participants were scanned at six time points in a day, during resting-state and Psychomotor Vigilance Test (PVT).

Results: The study revealed a higher test-retest reliability for task-based CBF compared to resting-state, with a notable diurnal decline in reliability at 20:00, and showed a decline with time intervals.

Impact: These findings underscore the importance of accounting for diurnal variations when designing functional MRI studies to ensure reliable and reproducible results, especially suggest avoiding nighttime data collection.

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