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Abstract #4254

GAGA: Gapped Arrangement of Golden Angles for sliding window reconstruction of hyperpolarized dynamic 13C MRSI data acquired with 3D radial EPSI

Gino Gianfranco Rincon1,2,3, Marcel Awenius1,2,4, Helen Abeln1,4,5, Philipp Biegger1, Melanie Müller1, Vanessa Franke1, Andreas B. Schmidt3,6,7, Mark E. Ladd1,2,8, Peter Bachert1,2, and Andreas Korzowski1,3
1Division of Medical Physics in Radiology, German Cancer Research Center (DKFZ), Heidelberg, Germany, 2Faculty of Physics and Astronomy, University of Heidelberg, Heidelberg, Germany, 3German Cancer Consortium (DKTK), Heidelberg, Germany, 4International Max Planck Research School for Quantum Dynamics in Physics, Chemistry, and Biology (IMPRS-QD), Max Planck Institute for Nuclear Physics (MPIK), Heidelberg, Germany, 5Institute of Organic Chemistry, University of Heidelberg, Heidelberg, Germany, 6Department of Radiology, Medical Center University of Freiburg, Freiburg, Germany, 7Faculty of Medicine, University of Freiburg, Freiburg, Germany, 8Faculty of Medicine, University of Heidelberg, Heidelberg, Germany

Synopsis

Keywords: Data Acquisition, Data Acquisition

Motivation: Hyperpolarized 13C magnetic resonance spectroscopic imaging (13C-MRSI) provides real-time metabolic insights but requires extremely fast and efficient imaging sequences, especially for dynamic measurements.

Goal(s): This work aims to enhance three-dimensional 13C radially-sampled echo-planar spectroscopic imaging (rEPSI) to enable dynamic acquisitions.

Approach: A novel algorithm for a 3D Gapped Arrangement of Golden Angles (GAGA) is introduced, combined with sliding window (SW) reconstruction, and tested in simulation and phantom studies.

Results: The algorithm developed for GAGA creates homogeneous k-space sampling distributions for individual temporal subframes, and SW reconstruction successfully recovers the temporal dynamics while displaying only minor temporal flickering and incoherent undersampling artifacts.

Impact: The novel algorithm for a Gapped Arrangement of Golden Angles (GAGA) enables dynamic measurements of volumetric hyperpolarized 13C MRSI with a high temporal resolution. Further studies will exploit its potential for the investigation of metabolic processes using dynamic hyperpolarized 13C-MRSI.

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Abstract

Keywords