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Abstract #4271

Unsupervised MRI Super-Resolution Reconstruction Using a Hybrid Regularizer Powered Deep Image Prior

Yuxiang Zhong1, Lixian Zou1, Futao Chen1,2, Qian Li1, Bing Zhang2, Ye Li1,3,4, Dong Liang1,3,4, Xin Liu1,3,4, Hairong Zheng1,3,4, and Na Zhang1,3,4
1Paul C. Lauterbur Research Center for Biomedical Imaging, Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences, Shenzhen, China, 2Department of Radiology, The Affiliated Drum Tower Hospital of Nanjing University Medical School, Nanjing, China, 3Key Laboratory of Biomedical Imaging Science and System, Chinese Academy of Sciences, Shenzhen, China, 4United Imaging Research Institute of Innovative Medical Equipment, Shenzhen, China

Synopsis

Keywords: Image Reconstruction, Brain

Motivation: While deep networks have shown great effectiveness for post-acquisition MRI resolution enhancement, their training requires an enormous of datasets. Deep Image Prior (DIP) is a novel approach that leverages the inductive bias of deep convolutional architecture, allowing for MRI super-resolution without the need for training.

Goal(s): We aim to improve the capabilities of DIP and thus achieve resolution enhancement.

Approach: We introduced a hybrid regularizer that integrates total variation with a neural network denoiser into the DIP framework.

Results: Validated on 5T MR datasets, our method further improved on DIP and generated high-resolution MRI with realistic details, outshining several competing methods.

Impact: The proposed unsupervised method offered a robust framework for MRI super-resolution reconstruction that leverages intrinsic image structure to ensure resolution enhancement without the need for training data, thus boosting the efficiency of medical imaging and potentially benefiting clinical diagnostics.

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