Abstract #4284

High Resolution MRI Protocol for Ovarian Cancer Screening

Summer Joyce Batasin¹, Hon J Yu¹, Sheida Ebrahimi¹, Stephane Loubrie¹, Christopher Conlin¹, Thien Truong¹, Breana Hill², Michael McHale³, Cynthia Santillan¹, and Rebecca Rakow-Penner^1,4

¹Radiology, University of California, San Diego, San Diego, CA, United States, ²Gynecology Oncology, University of California, San Diego, San Diego, CA, United States, ³Obstetrics, Gynecology, & Reproductive Sciences, University of California, San Diego, San Diego, CA, United States, ⁴Bioengineering, University of California, San Diego, San Diego, CA, United States

Synopsis

Keywords: Pelvis, Pelvis, Ovary, Diffusion

Motivation: Addressing the critical need for improved ovarian cancer detection, given its high mortality rate and limited screening options.

Goal(s): Explore diffusion properties of normal ovaries and lesions at high b-values (>1000 s/mm² to develop a high-resolution ovarian cancer screening (OCS) protocol for average and high-risk individuals.

Approach: Utilized multishell diffusion-weighted MRI (DW-MRI) with simultaneous multi-slice excitation (Multiband) to capture high-resolution images in healthy, high-risk BRCA 1/2, and patients with potential cancer based on prior imaging.

Results: Distinct abnormal lesion types exhibited distinct contrasts at high b-values, with normal ovaries showing no signal, as expected.

Impact: Preliminary ovarian cancer MRI results with multishell DWI with Multiband, show promise in a new screening tool for ovarian cancer screening. This marks a significant step toward non-invasive screening advancements for high-risk individuals and early detection strategies.

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