Abstract #4307

Radiomic Features of Placental Magnetic Resonance Imaging Identify Adverse Pregnancy Outcomes: A Pilot Study

Quyen N. Do¹, Yin Xi¹, Matthew A. Lewis¹, Baowei Fei^2,3, Catherine Y. Spong^4,5, Diane M. Twickler^1,4,5, and Christina L. Herrera^4,5

¹Radiology, UT Southwestern Medical Center, Dallas, TX, United States, ²Bioengineering, The University of Texas at Dallas, Richardson, TX, United States, ³Center for Imaging and Surgical Innovation, The University of Texas at Dallas, Richardson, TX, United States, ⁴Obstetrics & Gynecology, UT Southwestern Medical Center, Dallas, TX, United States, ⁵Parkland Health, Dallas, TX, United States

Synopsis

Keywords: Placenta, MR Value, chronic hypertension, radiomic analysis, preeclampsia, small for gestational age

Motivation: Chronic hypertension (cHTN) is a significant obstetric condition with increased risk of adverse outcomes. Radiomic analysis of MR images may be able to predict outcomes before development of clinical findings.

Goal(s): Our goal was to compare MR T2W radiomic features among 4 clinical outcomes: normal, cHTN, preeclampsia with severe features, and small for gestational age (SGA).

Approach: We applied ROI-based radiomics analysis on prospectively collected T2W MR images in normal and cHTN pregnancies.

Results: We found that MR T2W radiomic features as early as 16 weeks can identify those patients who develop preeclampsia with severe features and whose infants are born SGA.

Impact: We demonstrated that MR T2W radiomic features as early as 16 weeks can identify those patients who develop preeclampsia with severe features and whose infants are born small for gestational age.

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