Abstract #4340

Beyond the dipole: unveiling the hidden impact of nondipolar shifts on MRI phase contrast anisotropy in the brain

Thomas Jochmann^1,2, Niklas Kügler¹, Ahmad Omira¹, Robert Zivadinov^2,3, Jens Haueisen¹, and Ferdinand Schweser^2,3

¹Department of Computer Science and Automation, Technische Universität Ilmenau, Ilmenau, Germany, ²Buffalo Neuroimaging Analysis Center, Department of Neurology at the Jacobs School of Medicine and Biomedical Sciences, University at Buffalo, The State University of New York, Buffalo, NY, United States, ³Center for Biomedical Imaging, Clinical and Translational Science Institute, University at Buffalo, The State University of New York, Buffalo, NY, United States

Synopsis

Keywords: Quantitative Imaging, Quantitative Susceptibility mapping

Motivation: To elucidate the contribution of nondipolar frequency shifts to the anisotropy of phase contrast in brain MRI and decode the underpinning biophysical mechanisms of phase contrast.

Goal(s): To differentiate the roles of magnetic susceptibility and nondipolar frequency shifts across various head orientations in MRI scans.

Approach: Utilizing DEEPOLE QUASAR, the study compares susceptibility estimates and nondipolar frequency shifts in anisotropic brain regions across multiple head orientations.

Results: Nondipolar frequency shifts played a substantial role in the anisotropy of frequency shifts, with DEEPOLE QUASAR providing more stable susceptibility estimates than conventional QSM, regardless of head orientation.

Impact: The study establishes the substantial influence of nondipolar frequency shifts on MRI phase contrast anisotropy, questioning established assumptions from susceptibility tensor imaging and quantitative susceptibility mapping, thereby paving the way for more accurate brain tissue characterization.

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