Abstract #4348

Evaluating the Prognostic Potential of High-Water Content Regions in Parkinson's Cognitive Impairment Progression

Mariyemuguli Reheman¹, Naying He¹, Sagar Buch², Huang Pei ³, Peng Wu⁴, Shengdi Chen³, Haacke E. Mark^2,5, and Fuhua Yan¹

¹Department of Radiology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China, ²Department of Radiology, Wayne State University, Detroit, MI, United States, ³Department of Neurology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China, Shanghai, China, ⁴Philips Healthcare, Shanghai, China, ⁵Department of Neurology, Wayne State University, Detroit, MI, United States

Synopsis

Keywords: Parkinson's Disease, White Matter

Motivation: White matter damage has been known to accumulate prior to the onset of white matter hyperintensity, but there is currently no way to calculate the extent of damage.

Goal(s): Quantification of high-water content regions in Parkinson's patients based on proton spin density maps provides a new biomarker for mapping tissue damage and interpretation of WMH evolution.

Approach: Distribution of high-water content regions and WMH were mapped for Parkinson patients with different cognitive levels. Heatmaps were created for groups.

Results: High water content regions were mainly distributed along the ventricular wall. Water content and WMH correlated with CSF volumes with significant differences between groups.

Impact: Segmentation of the high-water content regions based on proton spin density maps provides the ability to interpret WMH evolution and provide a new potential biomarker to guide the early detection. These effects were dramatically seen in Parkinson’s patients with dementia.

How to access this content:

For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.

After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.

After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.

Click here for more information on becoming a member.