Keywords: Parkinson's Disease, Neuroscience
Motivation: Functional connectivity between white-matter networks maybe a neuroimaging biomarker of PD with L-dopa induced dyskinesia (LID).
Goal(s): The aim of this research is to investigate changes of the white-matter functional networks in PD with LID.
Approach: The construction of white-matter network was achieved by using K-means clustering while FC was also calculated.
Results: A decreasing trend (not significant) was also found between LID and noLID group. FC between WM2 and WM11 in LID group showed a significantly positive correlation with MMSE, while a negative relation between FC and MMSE was found in noLID group.
Impact: The study showed that decreased FC between white-matter networks and their influence on clinical performance may indicated the appearance of PD and symptom of LID.
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