Abstract #4355

Optimal deep brain stimulation sites pathways and networks for different Symptoms in Dystonia

Yan Li¹, Suzhen Lin², Chencheng Zhang³, Naying He¹, Chengyan Wang⁴, Peng Wu⁵, Dianyou Li³, Yiwen Wu², and Fuhua Yan^1,6

¹Department of Radiology, Ruijin Hospital， Shanghai Jiao Tong University School of Medicine, Shanghai, China, ²Department of Neurology & Institute of Neurology, Ruijin Hospital， Shanghai Jiao Tong University School of Medicine, Shanghai, China, ³Department of Neurosurgery, Center for Functional Neurosurgery, Ruijin Hospital， Shanghai Jiao Tong University School of Medicine, Shanghai, China, ⁴Human Phenome Institute, Fudan University, Shanghai, China, ⁵Philips Healthcare, Shanghai, China, ⁶Faculty of Medical Imaging Technology, College of Health Science and Technology, Shanghai Jiao Tong University School of Medicine, Shanghai, China

Synopsis

Keywords: Parkinson's Disease, Neuroscience

Motivation: STN-targeted DBS shows promise in Dystonia treatment. However, optimal stimulation sites, pathway modulation, and network effects for different dystonia subtypes are unknown.

Goal(s): To examine stimulation sites, pathway modulation, and network effects in dystonia subtypes for personalized DBS interventions.

Approach: Retrospective study of 71 dystonia patients undergoing STN-DBS. Clinical outcomes assessed with Burke-Fahn-Marsden Dystonia Rating Scale. Imaging, tissue activation estimation, and pathway/network reconstruction performed using Lead-DBS and Iso2Mesh toolbox.

Results: Subtypes have varied stimulation sites. Orofacial group shows positive correlations between VTA-STN intersection and clinical improvement. Dorsolateral STN effective for orofacial and hindlimb symptoms. Targeting lenticular fasciculus benefits orofacial dystonia.

Impact: Study proposes a comprehensive model for personalized DBS, improving treatment strategies. Further research needed to validate targets, pathways, and networks, enhancing clinical decision-making and outcomes.

How to access this content:

For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.

After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.

After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.

Click here for more information on becoming a member.