Keywords: Other Neurodegeneration, Arterial spin labelling
Motivation: To explore the relationship between hippocampal perfusion asymmetry and hippocampal enlarged perivascular spaces (H-EPVS) and cognitive function in patients with T2DM.
Goal(s): To explore the relationship between hippocampal perfusion asymmetry and H-EPVS and cognitive function in patients with T2DM.
Approach: CBF in hippocampus,H-EPVS and cognitive function were compared between HCs and patients with T2DM .The relationship between CBF in hippocampus, H-EPVS counts and cognitive measurement was analyzed.
Results: In patients with T2DM, hippocampal perfusion was reduced and H-EPVS counts were higher on the left side. Decreased right hippocampal perfusion and increased left H-EPVS count were associated with cognitive impairment in patients with T2DM .
Impact: Asymmetric impairment of hippocampal in patients with T2DM , and the asymmetry may be caused by a variety of mechanisms and may contribute to cognitive impairment.
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