Abstract #4372

Hemoglobin A and S affects blood R1 differently: a comparative study in healthy controls and sickle cell disease patients

Chunwei Ying¹, Cihat Eldeniz¹, Lucas Musibay², Jenny Yoo³, Slim Fellah⁴, Josiah Lewis⁴, Amy Mirro⁵, Yan Yan⁶, Yasheng Chen⁴, Yan Wang⁴, Michael Binkley⁴, Jin-Moo Lee^1,4, Melanie E. Fields^4,5, Kristin Guilliams^4,5, Andria L. Ford^1,4, and Hongyu An^1,4

¹Mallinckrodt Institute of Radiology, Washington University School of Medicine, St. Louis, MO, United States, ²Department of Biology, Washington University in St. Louis, St. Louis, MO, United States, ³Department of Biomedical Engineering, Washington University in St. Louis, St. Louis, MO, United States, ⁴Department of Neurology, Washington University School of Medicine, St. Louis, MO, United States, ⁵Department of Pediatrics, Washington University School of Medicine, St. Louis, MO, United States, ⁶Department of Surgery, Washington University School of Medicine, St. Louis, MO, United States

Synopsis

Keywords: Other Neurodegeneration, Relaxometry, sickle cell disease, blood longitudinal relaxation rate, hematocrit, hemoglobin

Motivation: Blood R1 (R1_Blood) is associated with hematocrit level (Hct). However, it is unclear whether Hct of normal hemoglobin (HctA) and sickle hemoglobin (HctS) have a similar impact on R1_Blood.

Goal(s): Evaluate the impact of HctA and HctS on R1_Blood in healthy controls and SCD patients.

Approach: Multiple linear regression with R1_Bloodas the dependent variable and Hct of combined hemoglobin A and F (HctAF), HctS, age, and sex as independent variables was performed.

Results: R1_Blood was associated with HctAF, HctS, age, and sex. Moreover, the association between R1_Blood and HctS was significantly different from that between R1_Blood and HctAF.

Impact: Blood R1 is essential in various MRI applications. Our findings are crucial for developing an accurate blood R1 estimation model in sickle cell disease patients.

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