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Abstract #4373

Effect of Nicotinamide riboside supplementation on cerebral NAD+ levels in vivo

Ravi Prakash Reddy Nanga1, Corinde E Wiers2, Mark A Elliott1, Neil E Wilson1, Fang Liu3, Quy Cao3, Sophie Swago4, Paul S Jacobs4, Ryan Armbruster4, Damodara Reddy1, Walter R Witschey1, John A Detre5, Joseph Baur6, and Ravinder Reddy1
1CAMIPM, Radiology, Perelman School of Medicine at The University of Pennsylvania, Philadelphia, PA, United States, 2Psychiatry, Perelman School of Medicine at The University of Pennsylvania, Philadelphia, PA, United States, 3Biostatistics, Epidemiology, and Informatics, Perelman School of Medicine at The University of Pennsylvania, Philadelphia, PA, United States, 4Bioengineering, School of Engineering and Applied Sciences, University of Pennsylvania, Philadelphia, PA, United States, 5Neurology, Perelman School of Medicine at The University of Pennsylvania, Philadelphia, PA, United States, 6Physiology, Institute for Diabetes, Obesity and Metabolism, Perelman School of Medicine at The University of Pennsylvania, Philadelphia, PA, United States

Synopsis

Keywords: Aging, Translational Studies, Brain, Nicotinamide adenine dinucleotide, NAD+, Nicotinamide ribosome, NR, 1H MRS, Aging

Motivation: To determine if acute nicotinamide riboside (NR) supplementation increases cerebral nicotinamide adenine dinucleotide (NAD+) levels in the human brain.

Goal(s): To measure cerebral NAD+ levels before and after nicotinamide riboside supplementation using downfield 1HMRS at 7T MRI in ten healthy volunteers.

Approach: First MR scan was performed in each healthy volunteer after overnight fasting to obtain baseline NAD+ levels. In the second scan on the following day, the same protocol was repeated, but with NR supplements administered orally 4 hours before the scan.

Results: An increase in mean NAD+ concentration was observed with NR supplementation, compared to the baseline (0.458±0.053 vs 0.392±0.058mM; p<0.001).

Impact: The preliminary results from this study show that oral NR supplementation increases NAD+ levels in brain and demonstrates the potential of downfield 1HMRS for noninvasive quantification of cerebral NAD+ and monitoring the effects of NR supplementation on cerebral NAD+ levels.

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Abstract

Keywords