Keywords: Parkinson's Disease, Parkinson's Disease
Motivation: Parkinson disease patients show alterations in their vascular system, exhibiting lower perfusion than healthy subjects.
Goal(s): Here, we harness a mouse model exhibiting extensive human α-syn deposition to investigate cerebral blood flow properties in PD.
Approach: We use a novel setup enabling high resolution Pseudo-Continuous Arterial Spin Labelling, a non-invasive technique for perfusion mapping in-vivo without injection of contrast agentes.
Results: We found that not only the PD mouse line but also their WT littermates have altered perfusion properties across the brain compared to control c57bl/6 mice.
Impact: Our findings highlight the importance of accounting for these potential sources of variability in future work with these lines.
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