Keywords: Parkinson's Disease, Parkinson's Disease
Motivation: Delayed detection of wearing off (WO) in Parkinson’s disease (PD) has a negative impact on quality of life. However, there is currently no method for WO prediction prior to treatment.
Goal(s): To investigate whether resting-state functional MRI (rs-fMRI) could aid in WO prediction.
Approach: Fractional amplitude of low-frequency fluctuation (fALFF) was quantified from rs-fMRI to determine whether spontaneous activity dysfunction could be a predisposing vulnerability related to WO.
Results: Putaminal fALFF reduction was the independent predictor of WO development.
Impact: Detection of putaminal fALFF reduction prior to treatment provides a quantitative metric to facilitate WO prediction and improve prognosis.
How to access this content:
For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.
After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.
After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.
Keywords