Keywords: Parkinson's Disease, Parkinson's Disease
Motivation: Early detection of Parkinson's disease (PD) is crucial, and MRI has been a valuable tool. Synthetic MRI, allows for comprehensive analysis of brain regions, offering potential for early diagnosis.
Goal(s): Evaluate the feasibility of synthetic MRI in early PD diagnosis by studying brain regions.
Approach: 31 PD patients and 25 controls underwent MRI. Synthetic MRI provided T1, T2, and PrD maps. Brain regions were analyzed and a combined diagnostic model was developed.
Results: Differences in T1 and T2 values were found in the calcarine, cuneus, and hippocampus. The model achieved an AUC of 0.930, suggesting synthetic MRI-derived parameters can serve as biomarkers.
Impact: The combined diagnosis using T1 and T2 values in specific brain regions effectively distinguished early-stage Parkinson's disease (ESP) from healthy controls (HC). This suggests that synthetic MRI-derived parameters have the potential to serve as precise early PD diagnostic biomarkers.
How to access this content:
For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.
After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.
After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.
Keywords