Abstract #4385

Arterial spin labeling-based machine learning for idiopathic rapid eye movement sleep behavior disorder and Parkinson's disease

Mingshen Chen¹, Yuqi Zhi², Huihui Lin², Yiwen Xu², Tong Chen², Xiaoyu Cheng³, Chengjie Mao³, Zhen Jiang², Xiaoyun Liang^4,5, Yunzhu Wu⁶, Bo Peng¹, Yakang Dai¹, and Jiangtao Zhu²

¹Suzhou Institute of Biomedical Engineering and Technology, Chinese Academy of Sciences, Suzhou, Jiangsu, People’s Republic of China, suzhou, China, ²Department of Radiology, The Second Affiliated Hospital of Soochow University, Suzhou, Jiangsu, People’s Republic of China, suzhou, China, ³Department of Neurology, The Second Affiliated Hospital of Soochow University, Suzhou, Jiangsu, People’s Republic of China, suzhou, China, ⁴Institute of Artificial Intelligence and Clinical Innovation, Neusoft Medical Systems Co., Ltd., Shanghai, People’s Republic of China, shanghai, China, ⁵Florey Institute of Neuroscience and Mental Health, The University of Melbourne, Melbourne, VIC, Australia, Melbourne, Australia, ⁶MR Research Collaboration Team, Siemens Healthineers Ltd. Shanghai, China., shanghai, China

Synopsis

Keywords: Parkinson's Disease, Arterial spin labelling, Neurodegenration, Neuroscience

Motivation: Investigating cerebral blood flow (CBF) alterations between idiopathic REM sleep behavior disorder (iRBD) and Parkinson's disease (PD) using arterial spin labeling (ASL) can provide crucial insights into the shared neurobiological underpinnings of these conditions, facilitating effective disease management and treatment.

Goal(s): Analyzing the cerebral blood flow (CBF) variations and CBF-connectivity and evaluating their diagnostic utility.

Approach: By employing ASL, we conducted a detailed analysis of CBF variations and constructed a CBF-connectivity network.

Results: Observed increased CBF in PD vs iRBD in specific regions, as well as elevated connectivity.

Impact: The present study provides objective biomarkers for the progression of iRBD and PD through the study of cerebral perfusion. It also provides direction for adjunctive treatment of microcirculatory abnormalities to further inhibit the progression of associated dysfunction.

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