Abstract #4384

Accuracy of AI-driven susceptibility map-weighted MRI analyses to differentiate neurodegenerative from non-neurodegenerative parkinsonism

Elon D. Wallert¹, Elsmarieke van de Giessen², Martijn Beudel³, Dong Hoon Shin^4,5, Tom van Mierlo⁶, Jeroen Blankevoort⁷, Henk W. Berendse⁸, Rob M.A. de Bie³, and Jan Booij¹

¹Department of Radiology and Nuclear medicine, Amsterdam UMC, University of Amsterdam, Amsterdam, Netherlands, ²Department of Radiology and Nuclear medicine, Amsterdam UMC, Vrije Universiteit Amsterdam, Amsterdam, Netherlands, ³Department of Neurology, Amsterdam UMC, University of Amsterdam, Amsterdam, Netherlands, ⁴'Heuron Co., Ltd., Seoul, Korea, Republic of, ⁵Department of Neurology, Gachon University College of Medicine, Incheon, Korea, Republic of, ⁶Department of Neurology, Spaarne Gasthuis, Haarlem, Netherlands, ⁷Department of Neurology, Flevoziekenhuis, Almere, Netherlands, ⁸Department of Neurology, Amsterdam UMC, Vrije Universiteit Amsterdam, Amsterdam, Netherlands

Synopsis

Keywords: Parkinson's Disease, Parkinson's Disease

Motivation: Susceptibility map-weighted imaging (SMWI) of the substantia nigra is a novel MRI sequence that has the potential to aid the diagnosis of patients with clinically uncertain parkinsonian syndromes (CUPS).

Goal(s): To investigate the accuracy of AI-driven automated SMWI software in a clinically relevant population.

Approach: We acquired SMWI in patients who received a dopamine transporter (DAT)-SPECT because of CUPS. The diagnostic software (Heuron IPD) results were compared with the DAT-SPECT results as a reference.

Results: Preliminary analysis of 120 patients demonstrated an accuracy of 88% for the diagnostic software to differentiate neurodegenerative from non-neurodegenerative parkinsonism in patients who presented with CUPS.

Impact: Susceptibility map-weighted imaging (SMWI) demonstrates a diagnostic accuracy of 88% in patients with clinically uncertain parkinsonian syndromes (CUPS). These findings are promising for the use of SWMI as diagnostic marker and warrant prospective studies in CUPS patients.

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