Abstract #4393

Abnormal Resting-state Functional Connectivity and cerebral blood flow in Overactive Bladder Syndrome

Shichun Chen¹, Zongpai Zhang¹, Yakun Zhang¹, Kenneth Wengler², Justina Tam³, Steven Weissbart³, Weiying Dai¹, and Xiang He⁴

¹Computer Science, State University of New York at Binghamton, Binghamton, NY, United States, ²New York State Psychiatric Institute, New York, NY, United States, ³Urology, State University of New York at Stony Brook, Stony Brook, NY, United States, ⁴Radiology, State University of New York at Stony Brook, Stony Brook, NY, United States

Synopsis

Keywords: Functional Connectivity, Perfusion, fMRI (resting state)

Motivation: Overactive Bladder (OAB) significantly impacts patients' quality of life. However, the brain-bladder control mechanism during the bladder filling was not known.

Goal(s): To investigate abnormality of cerebral blood flow (CBF) and functional connectivity (FC) during the bladder filling in OAB patients.

Approach: Arterial spin labeling (ASL) images were acquired with bladder filling volumes of 0, 50, 100, 200, 350 and 500mL.

Results: We observed medio-prefrontal cortex (mPFC) CBF and mPFC-PCC (posterior cingulate cortex) FC are compromised in OAB patients during bladder filling.

Impact: We offered a new perspective for the role of ASL perfusion and functional connectivity in understanding brain mechanism that controls urinary continence. ASL may be used to monitor treatment effects of OAB patients.

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