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Abstract #4400

Radiomic analysis of quantitative T2-mapping and conventional MRI in predicting histologic grade of bladder cancer

Ye Lei1, Xiaoxiao Zhang2, Yuntian Chen3, Wanxin Xiang3, Jin Yao3, Bin Song3, and Ye Lei1
1West China Hospital, Sichuan University, Chengdu, China, ChengDu, China, 2Department of Clinical, Philips Healthcare, China, Chengdu, China, 3West China Hospital, Sichuan University, Chengdu, China, Chengdu, China

Synopsis

Keywords: fMRI Analysis, Bladder, pathological grade

Motivation: MpMRI has been extensively used for the local staging of bladder cancer (BCa), it is worth using mpMRI for the preoperative evaluation of the pathological grade.

Goal(s): We explored the added value of a radiomics based on quantitativeT2-mapping and conventional MRI to evaluate the histologic grade of BCa pre-operatively.

Approach: Pelvic MRI including T2-mapping and diffusion-weighted imaging before any treatment were analyzed. We constructed different prediction models using mean signal values and radiomic features from both T2-mapping and apparent diffusion coefficient (ADC) maps.

Results: Radiomics could provide more information than direct evaluation of T2 and ADC values in differentiating histological grades of BCa.

Impact: Our observation of significantly improved performance using the radiomics model suggests that it incorporates tumor appearance, margin, and texture features, making it more representative of tumor characteristics. The incorporation of this model provides valuable additional information for BCa management.

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Keywords