Keywords: fMRI Analysis, fMRI (resting state), Cerebral small vessel disease; FOCA; SVD score
Motivation: Cerebral small vessel disease (SVD) affects older adults, but traditional approaches have limited understanding of the neural mechanisms of SVD.
Goal(s): To explore the effects of SVD on brain regions and its relationship to cognitive decline by FOCA method.
Approach: MRI data from 42 SVD patients and 38 controls were analyzed using FOCA values, and the correlation between FOCA values of SVD patients and SVD score was explored.
Results: Different FOCA value changes in SVD patients were associated with regions of cognitive function.
Impact: This study has the potential to improve our understanding of the neural mechanisms of SVD, suggesting that FOCA values provide a new method to analyzing changes in cognitive function.
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