Abstract #4419

Regional impairments in cerebrovascular reactivity in Fontan patients: fMRI CO2 challenge

Botian Xu^1,2, Clio González-Zacarías^2,3, Sneha Verma², Emma Carpenter², Jian Shen^1,2, Soyoung Choi⁴, Silvie Suriany², Peter Chiarelli⁵, Anand Joshi³, Richard Leahy³, and John Wood^2,6

¹Department of Biomedical Engineering, University of Southern California, Los Angeles, CA, United States, ²Cardiology, Children's Hospital Los Angeles, Los Angeles, CA, United States, ³Ming Hsieh Department of Electrical and Computer Engineering, University of Southern California Viterbi School of Engineering, Los Angeles, CA, United States, ⁴Institute of Imaging Science, Vanderbilt University, Nashville, TN, United States, ⁵Pediatric Neurosurgery, Children's Hospital Los Angeles, Los Angeles, CA, United States, ⁶Pediatrics CHLA, Keck School of Medicine of USC, Los Angeles, CA, United States

Synopsis

Keywords: fMRI Analysis, fMRI (resting state), Fontan, cerebrovascular reserve, CVR, BOLD

Motivation: Despite their high risk for cerebral injuries and neurocognitive deficits, cerebrovascular health in single ventricle heart disease (SVHD) patients is understudied.

Goal(s): Quantifying cerebrovascular reserve (CVR) in SVHD patients will determine the susceptibility of these patients to acute interruptions in oxygen delivery or increased metabolic demand.

Approach: In this study, we used blood oxygenation level-dependent BOLD-MRI under CO2 challenge to measure CVR in patients who underwent Fontan palliation and in control subjects.

Results: Regional, but not global differences, were shown in CVR between Fontan versus healthy controls.

Impact: An important prognostic indicator of cerebrovascular integrity is the ability of blood vessels to dilate or constrict in response to a stimulus, measured by CVR. Therefore, quantifying CVR in SVHD patients will determine their susceptibility to increased metabolic demands.

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