Keywords: CEST / APT / NOE, CEST & MT, Z-spectral fitting, olephinic fat, aliphatic fat
Motivation: Fat-artifacts are challenging in CEST-MRI for body applications as they overlap spectrally with clinically relevant signals like amide or hydroxyl.
Goal(s): Improve the quality of in vivo fat correction based on previously explored Z-spectral fitting of data obtained with SPIR fat suppression.
Approach: Olefinic fat is modeled separately while scaling and inverting aliphatic components. Fitting was tested on Z-spectral data from breast ROIs with variable fat content.
Results: The new model is accurate for a large range of fat fractions. The opposite phase of aliphatic and olefinic fat components provides a better explanation for the observed Z-spectra in vivo.
Impact: Understanding and accurate modeling of fat signals in fat-suppressed APT/CEST-MRI will allow unbiased assessment of CEST effects in body-oncology (breast, kidney cancer).
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