Abstract #4452

Renal Metabolic CEST-MRI Based on Golden-Angle Radial Sampling Under Free Breathing

Quan Tao^1,2,3, Zelong Chen⁴, Zhigang Wu⁵, Kan Deng⁶, Yizhe Zhang^2,3,7, Qianqian Zhang^2,3,7, Wenyan Zhang^2,3,7, Ting Lin⁸, and Yanqiu Feng^1,2,3,7

¹Department of Rehabilitation Medicine, Zhujiang Hospital, Southern Medical University, Guangzhou, China, ²Guangdong Provincial Key Laboratory of Medical Image Processing, Southern Medical University, Guangzhou, China, ³Guangdong Provincial Engineering Laboratory for Medical Imaging and Diagnostic Technology, Guangzhou, China, ⁴Medical Imaging Center, Nanfang Hospital, Southern Medical University, Guangzhou, China, ⁵Philips Healthcare, Shenzhen, China, ⁶Philips Healthcare, Guangzhou, China, ⁷School of Biomedical Engineering, Southern Medical University, Guangzhou, China, ⁸Department of Radiology, Zhujiang Hospital, Southern Medical University, Guangzhou, China

Synopsis

Keywords: CEST / APT / NOE, Kidney

Motivation: Respiration motion may induce artifact in CEST image and the in-accurate quantization of CEST signal.

Goal(s): We aimed to develop clinical motion-insensitive CEST imaging of kidney.

Approach: Here, we used turbo filed echo (TFE) based on golden-angle radial sampling to readout renal CEST image under free breathing of three normal volunteers and also evaluated its effectiveness for motion artifact suppression.

Results: The renal Z-spectrum is float and there is no motion artifact in CEST images. This motion in-sensitive sequence showed high repeatability for renal CEST imaging.

Impact: It may provide a motion in-sensitive CEST imaging sequence for renal imaging in clinical nephropathy patients under free breathing, and improve the accuracy of injury detection.

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