Keywords: Magnetization Transfer, Magnetization transfer, MR-Linac
Motivation: Quantitative magnetization transfer (qMT) could guide radiotherapy on MRI-linear accelerators (MR-Linacs), but limited scan time requires a fast sequence. Fast 3D qMT is possible with balanced steady-state free precession (bSSFP) or echo-planar imaging (EPI), but which method is superior is unclear.
Goal(s): Our goal was to determine whether bSSFP or EPI qMT on a 1.5T MR-Linac was best for imaging glioblastoma patients.
Approach: Eight patients were scanned using both methods. Repeatability in normal tissue and magnitude of tumor changes were compared.
Results: A 2 minute 20 second EPI qMT scan was more repeatable than bSSFP qMT and detected greater tumor changes.
Impact: The improvement in quantitative magnetization transfer acquisition speed through using 3D EPI enables integration into MR-Linac radiotherapy workflows, an unmet need as qMT can detect white matter changes which could be used to assess tumor response during treatment.
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