Abstract #4467

A Simple Approach for Quantifying T1 and Macromolecular Proton Fraction from Rapid Inversion Recovery with 3D stack-of-spiral FLASH readout

Zhen Hu¹, Dan Zhu^2,3, Yuguo Li^2,3, Jiadi Xu^2,3, and Qin Qin^2,3

¹Department of Biomedical Engineering, Johns Hopkins University School of Medicine, Baltimore, MD, United States, ²Russell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, MD, United States, ³The F.M. Kirby Research Center for Functional Brain Imaging, Kennedy Krieger Institute, Baltimore, MD, United States

Synopsis

Keywords: Magnetization Transfer, Magnetization transfer, T1, stack-of-spiral FLASH

Motivation: Simultaneous Quantification of T1 and macromolecular proton fraction (f_m) is desired but current methods are time consuming.

Goal(s): To develop an approach for quantitative mapping of both apparent T₁ and f_M from inversion recovery (IR) curves.

Approach: IR curves with efficient 3D stack-of-spiral FLASH readout were fitted with a monoexponential function, extracting both the apparent T₁ and the inversion degree with the latter to determine f_m. This method was evaluated through theory, simulation, phantom, and brain experiments.

Results: This study demonstrated a simple and rapid approach for 3D mapping of both apparent T₁ and f_m.

Impact: A simple and rapid approach for quantitative mapping of both apparent T1 and macromolecular proton fraction (fm) will help understanding the T1 contrast mechanism and facilitate developing pathological biomarkers for various clinical applications.

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