Abstract #4473

A 3D steady-state CEST sequence for in vivo imaging of cerebral blood vessels at 3T

Chuyu Liu¹, Zhensen Chen^2,3, Zhongsen Li¹, Xubin Chai^4,5, Nan Gao¹, and Xiaolei Song¹

¹Center for Biomedical Imaging Research, Department of Biomedical Engineering, Tsinghua University, Beijing, China, ²Institute of Science and Technology for Brain-Inspired Intelligence, Fudan University, Shanghai, China, ³Key Laboratory of Computational Neuroscience and Brain-Inspired Intelligence (Fudan University), Ministry of Education, Shanghai, China, ⁴State Key Laboratory of Brain and Cognitive Science, Institute of Biophysics, Chinese Academy of Sciences, Beijing, China, ⁵Beijing Neurosurgical Institute, Capital Medical University, Beijing Tiantan Hospital, Beijing, China

Synopsis

Keywords: CEST / APT / NOE, CEST & MT

Motivation: Cerebral blood vessels play key roles in oxygen transportation and nutrition metabolism. MR angiography provides non-invasive and comprehensive information on vessel structure, blood volume and even oxygenation level. A metabolic MR imaging tool for vessels may facilitate more clinical needs.

Goal(s): To observe CEST signal in vessels including proteins and peptides, sugars and macromolecule that contains aliphatic protons.

Approach: We developed a 3D steady-state vessel-CEST sequence. Sequence parameters were optimized by simulation. Repeatability and difference between arteries and veins were investigated on 8 subujects.

Results: Preliminary results demonstrated good repeatability of the pulse sequence, and allow sensitive visualization of blood signal in vessels.

Impact: We developed a 3D steady-state CEST sequence for in vivo z-spectra analysis of cerebral vessels.Preliminary results demonstrated good repeatability of the sequence,and difference between arteries and veins were observed.These facts illustrated the potential value in diagnosis of blood metabolism-related diseases.

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