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Abstract #4513

Automated Quality Control for Arterial Spin Labelling (ASL) MRI Using a VAE-based Neural Network

Jian Hu1,2, Silvin P. Knight3, Bowen Deng4, Rose Anne Kenny3,5,6, Xin Chen7, and Michael Chappell1,2
1Mental Health & Clinical Neurosciences, School of Medicine, University of Nottingham, Nottingham, United Kingdom, 2Sir Peter Mansfield Imaging Centre, School of Medicine, University of Nottingham, Nottingham, United Kingdom, 3The Irish Longitudinal Study on Ageing (TILDA), School of Medicine, Trinity College Dublin, Dublin, Ireland, 4Computer Vision Laboratory, School of Computer Science, University of Nottingham, Nottingham, United Kingdom, 5Discipline of Medical Gerontology, School of Medicine, Trinity College Dublin, Dublin, Ireland, 6Mercer’s Institute for Successful Ageing (MISA), St. James’s Hospital, Dublin, Ireland, 7Intelligent Modelling&Analysis Group, School of Computer Science, University of Nottingham, Nottingham, United Kingdom

Synopsis

Keywords: Diagnosis/Prediction, Perfusion, Quality Control

Motivation: Quality Control (QC) of ASL data is primarily a manual and subjective process that is time-intensive and can yield inconsistent results due to rater variability, while existing tools provide limited diagnostic metrics mostly focused on specific error source.

Goal(s): To develop a QC detector to automatically detect outliers for ASL data.

Approach: VAE-GAN model was applied to extract the latent representation of ASL data by which the decision boundary can be determined.

Results: The AUROC of our QC detector on test dataset is 0.82 with accuracy=0.81.

Impact: Our QC detector could help radiologists and researchers working on ASL MRI to automatically identify outliers. Consequently, appropriate operations can be used to correct or exclude outliers to avoid biases in the outcomes and ensure accurate interpretations.

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